ABSTRACT Polymers have become a versatile tool in pharmaceutical chemistry through techniques and new formulation. This review presents an overview of the general topic of drug delivery polymers, places a particular focus on their specific contributions, and discusses significant issues like biocompatibility, controlled release and targeted delivery. Unlike previous reviews, it captures recent development on biodegradable, smart and stimuli-responsive polymers, abilities to improve therapy outcomes and patient adherence to treatments. Furthermore, this work also has enhanced understanding of advanced polymer-based systems such as polymeric nanoparticles, bioconjugation strategies and natural polymerbased systems with examples in various therapeutic areas. The review also stands for itself by expanding the discussion of regulatory and clinical realism difficulties as well as safety, efficacy, and acceptance considerations. In addition, it emphasizes the role of interdisciplinary and intersectoral cooperation as well as cross-country collaborations in developing polymers-based applications in precision medicine. In this way, this review provides a fresh view on both the present advancements and future possibilities of polymer-based technologies and dedicated therapeutic achievements globally to inspire researchers and practitioners.