CV

Mohd. Raghibul Hasan, Ph.D.

Assistant Professor

Head of Scientific Research Unit,

College of Applied Medical Sciences, Al-Quwayiyah

Shaqra University, Riyadh Province, KSA

Contact No.: +966-562416571;

Email: malhasn@su.edu.sa

Orchid id: 0000-0001-9099-9716

Google Scholar id.:https://scholar.google.com/citations?user=sT0vBXQAAAAJ&hl=en&oi=ao

 

• Educational Qualification:

• PhD in Biochemistry, March-2012

All India Institute of Medical Sciences (AIIMS), India’s most prestigious institute, New Delhi, India

Thesis title: Clinical and Functional Characterization of Genes with Altered Expression in Esophageal Cancer.

• Master of Science (MSc) in Biochemistry and Biotechnology, May, 2005

Madurai Kamaraj University, Madurai, Tamil Nadu, India

Thesis title: Isolation and characterization of Hemolysin gene from Salmonella typhi.

• PG. Diploma. Biochemical-technology, June, 2003

University of Delhi, South Campus, New Delhi, India

• BSc. (Honors) in Biochemistry, 2002

All India Institute of Medical Sciences (AIIMS), New Delhi, India

 

• RESEARCH GRANT (2)

• Received Institutional Funding from Shaqra University, MOE, Saudi Arabia - (IFP2021-045)-August 2021,  Title-Cytotoxic Effect of Ocimum sanctum Extract on Esophageal Squamous Cell Carcinoma cells, TE13.
• Research Grant: Received from Ministry of Health, Saudi Arabia Grant for Covid-19 Research 2020- 2021

• Teaching/ Postdoc Experiences: 10 years

• Assistant Professor in Biochemistry: Dec., 2018- till date (4 Year +)

College of Applied Medical Sciences, Al-Quwayiyah, Shaqra University, Riyadh Province, KSA

• Assistant Professor (Guest Teacher) : Dept. of Biochemistry: 1 year (Aug2017-2018)

Jamia Millia Islamia, (JMI) New Delhi, India

• Postdoctoral Research Associate (RA): 3 Years( Sep.2014- Sep 2017)

Molecular Biology Laboratory, Gastroenterology, AIIMS, New Delhi.

Project: Wnt/EMT signaling pathway in esophageal cancer

• Research Associate (RA): 9 months

Molecular Genetics laboratory: Dept. of Anatomy, AIIMS, New Delhi. Project: Male infertility and childhood cancers

• Scientist Lab. Operation: 15 months (March, 2012–June 2013).

PreventiNe Life Care Pvt. Ltd. in Navi Mumbai, India: Development of diagnostic kit for Inborn Errors of Metabolism

• Other Experiences
  • Senior Research Fellow (SRF): 3 years (2008-2011)

Department of Biotechnology (DBT), Ministry of Science and Technology, Government of India

• • Junior Research Fellow (JRF): 2 years (2006-2008): DBT, Ministry of Science and Technology, Government of India
• PUBLICATIONS: Scopus, SCIE, (15)

1. Tripathi H, Bhalerao P, Singh S, Arya H, Alotaibi BS, Rashid S, Hasan MR and Bhatt TK. Malaria therapeutics: are we close enough?  Parasites & Vectors (2023) 16:130 https://doi.org/10.1186/s13071-023-05755-8. (Q1; IF= 3.430)
2. Dewani AP, Vekariya HJ, Khan FR, Omar BIA, Binshaya AS, Alhazmi AYM, Hasan MR, Alotaibi BS, Chandewar AV, Stability indicating HPLC method for the simultaneous analysis of Gatifloxacin and Loteprednol in eyedrop formulation using design of experiment approach. Indian Journal of Chemical Technology Vol. 30, March 2023, pp. 187-197 DOI: 10.56042/ijct.v30i2.66233  (Q4; IF= 0.76)
3. Hasan MR, Alotaibi BS,  Althafar Z, Mujamammi A and Jameela Jafar. An update on the therapeutic anticancer potential of Ocimum sanctum L.: "Elixir of Life".Molecules 2023, 28(3),1193; https://doi.org/10.3390/molecules28031193) (Q1; IF=4.9)
4. Alsolais AM, Althafar ZM, Hasan MR, Hakami MA, Omar BIA, Hessien KBG, Alkhorayef N, Khan FR. Ranitidine contaminated with N-nitrosodimethylamine (NDMA) link to carcinoma:  A systematic review and meta-analysis. Journal of Pharmaceutical Negative Results. Vol. 14 No. 2 (2023) 2031–2043. https://doi.org/10.47750/pnr.2023.14.02.251 .  (Q4; IF=0.65).             

                                                                   

5. Hasan MR, Srivastava G, Alyass A, Sharma R, Saraya A, Chattopadhyay TK, DattaGupta S, Walfish PG, Chauhan SS, Ralhan R. Prediction of recurrence free survival for esophageal cancer patients using a protein signature based risk model. (Oncotarget. 2022 Sep 14;13:1020-1032. doi: 10.18632/oncotarget.10656. eCollection 2022.PMID: 36128326).                             (Q2; IF= 3.33)

 

6. Alotaibi BS, Joshi J, Hasan MR, Khan MS, Alharethi SH, Mohammad T, Alhumaydhi FA, Elasbali AM, Hassan MI.  Identifying Isoononin and Candidissiol as Rho-associated protein kinase 1 (ROCK1) inhibitors: a combined virtual screening and MD simulation approach. J. Biomol Struct Dyn. 2022, Aug 13;1-10. doi: 10.1080/07391102.2022.2111362.PMID: 35965440.                   (Q2; IF=4.15)                                                                                                                                       
7. Alnomasy SF, Alotaibi BS, Aldosari ZM, Mujamammi AH, Alzamami A, Anand P, Akhter Y, Khan FR, Hasan MR. Molecular interactions of Zyesami with the SARS-CoV-2 nsp10/nsp16 protein complex.  Comb Chem High Throughput Screen. 2022 Aug 16. doi: 10.2174/1386207325666220816141028. Online ahead of print.PMID: 35975856.                                                                  (Q4; IF= 1.339)

 

8. Hasan MR, Sharma R, Chattopadhyay TK, Saraya A, Gupta SD, Chauhan SS, Ralhan R. Mitogen Activated Protein Kinase KinaseKinase 3 (MEKK3) overexpression is an early event in Esophageal Tumorigenesis and is a predictor of poor disease prognosis.(BMC Cancer. 2014 Jan 2;14(1):2. doi: 10.1186/1471-2407-14-2. (Q2; IF= 4.4)

 

9. Hasan MR, Sharma R, Saraya A, Chattopadhyay TK, Gupta SD, Chauhan SS, Ralhan R. Slug is a poor prognostic marker for esophageal squamous cell carcinoma. (PLoS One. 2013 Dec 18;8(12):e82846. doi: 10.1371/journal.pone.0082846 . (Q1; IF= 3.75)

 

10. Hasan MR, Sharma R, Kausar T, Chauhan SS, Ralhan R. (2012). RNA-interference mediated down-regulation of TC21 sensitizes esophageal cancer cells to Cisplatin. World J. of Gastroenterology, 2012 August 21; 18(31): 4127-4135 . (Q1; IF= 5.74)

 

11. Kausar T, Sharma R, Hasan MR, Saraya A, Chattopadhyay TK, Gupta SD, Ralhan R. Overexpression of a splice variant of oncostatin M receptor beta in human esophageal squamous carcinoma. Cellular Oncology, 2011, Volume 34, Number 3, 177-187.                                                                                              (Q1; IF= 7.14) 
12. Kausar T, Sharma R, Hasan MR, Tripathi SC, Saraya A, Chattopadhyay TK, Gupta SD, RalhanR.Clinical significance of GPR56, Transglutaminase 2 and NF-kB in Esophageal Squamous Cell Carcinoma. Cancer Investigation, January 2011, Vol. 29, No. 1, Pages 42-48                                                                             (Q2; IF= 2.17)

 

13. Ralhan R, He HC, So AK, Tripathi SC, Kumar M, Hasan MR, Kaur J, Kashat L, Macmillan C, Chauhan SS, Freeman JL, Walfish PG. Nuclear and Cytoplasmic Accumulation of Ep-ICD Is Frequently Detected in Human Epithelial Cancers, PLOS One. 2010 Nov 30;5(11):e14130.                                                        (Q1; IF= 3.75)
14. Kausar T, Ahsan A, Hasan MR, Lin L, Beer DG, Ralhan R. Sperm protein 17 is a novel marker for predicting cisplatin response in esophageal squamous cancer cell lines. International J. of Cancer. 2010 Mar 15;126(6):1494-503.       (Q1; IF= 4.48)
15. Hasan MR, Chatttopadhyay TK, Gupta SD and Ralhan R. Clinical Significance of Slug in Esophageal Squamous Cell Carcinoma. Indian Journal of Clinical Biochemistry, Dec 2007, Vol. 22 (Supl.), pp 305                  (Q3; IF= 1.38)

 

5. Book Chapters Publication (2)

Book Chapters(IGI Global Book Publication USA., November 2020)-SCOPOUS

5. Chapter 1: CancerImmunotherapies Beyond check point inhibitors. Mohammad Raghibul Hasan1*, Bader Saud Altoaibi1, Sultan F. Alnomasy1, Khalid Umar Fakhri2, Advancements in Cancer Therapeutics 2020, IGI, Global Book Publication, PA, USA, November 2020, ISBN: 9781799865308.

5. Chapter 26: Obstructions in Nanoparticle Conveyance, Nano-Drug Retention and EPR effect in cancer therapies. Khalid Umar Fakhri1, Mohammad Raghibul Hasan2, Subash C Sonkar3, FarhanJalees Ahmad4, MoshahidAlam Rizvi1*Advancements in Cancer Therapeutics November 2020, IGI, Global Book Publication, PA, USA, November 2020, ISBN: 9781799865308.

 

5. Poster/ Oral Presentation

• International Conference Proceedings /Abstract/Poster/ Oral Presentation/: (11)

1. Hasan MR, SidharthaDatta Gupta, RanjuRalhan, Shyam S Chauhan, AnoopSaraya. Wnt Signaling Protein Expression Based Pridiction of Recurrent Free Survival in Esophageal Cancer; Digestive Disease Week, May 06 - 09, 2017, Chicago, Illinois, (USA).
2. Khan Imteyaz, Gupta Surabhi, Rashid Safoora, Hasan Raghibul, AnoopSaraya.Characterization of miRNAs in Chronic Pancreatitis and Pancreatic Cancer Using Next Generation Sequencing; Disease Week, May 06 - 09, 2017, Chicago, Illinois, (USA).
3. Hasan MR, SidharthaDatta Gupta, RanjuRalhan, Shyam S Chauhan, AnoopSaraya. Fascin-1 is a Potential Tissue Biomarker in Esophageal Squamous Cell Carcinoma (ESCC). 57th Annual Conference of Indian Society of Gastroenterology: 15th-18th Dec, 2016, New Delhi
4. Hasan MR, Sharma R, Saraya A, Chattopadhyay TK, Gupta SD, Chauhan SS, Ralhan R. Prognostic significance of MAP3K3(MEKK3) Overexpression in Esophageal Cancer. 3rd International Conference on Stem Cells and Cancer (ICSCC-2012):27-30 October 2012.
5. Hasan MR, Sharma R, Kausar T, Chauhan SS, Ralhan R. TC21 downregulation induces cisplatin sensitivity in esophageal cancer cells. Advances in Cancer Research: From the Laboratory to the Clinic. March 7-10, 2010 Dead Sea, Jordan
6. Hasan R, Sharma R, Chattopadhayay TK, Gupta SD, Chauhan SS, Ralhan R. Clinical significance of E-Cadherin and Slug in esophageal squamous cell carcinoma. 8th International Conference Focus: Lung & Esophageal Cancers, RGCON, March 27-29, 2009, Hayat Regency, Delhi.
7. Hasan MR, Chatttopadhyay TK, Gupta SD, Chauhan SS and Ralhan R. Clinical significance of Ecadherin and β-catenin expression in Esophageal Squamous Cell Carcinoma. 28th Annual Convention of Indian Association for Cancer Research and international Symposium on “Emerging Challenges in Approaches in Cancer Biology”. Feb. 21-24, 2009, IISc. Bangalore.
8. Hasan MR and Ralhan R. Effect of Curcumin on expression of β-Catenin/ WNT signaling in Esophageal Squamous Cell carcinoma cell line. International Symposium on “Novel Strategies for Targeted Prevention and Treatment of Cancer”. Dec. 19-20, 2008, JNU, New Delhi.
9. Kausar T, Lin L, Thomas D, Ahsan A, Hasan MR, Ralhan R and Beer DG. GPR56 is frequently overexpressed in esophageal adenocarcinoma and may affect tumor invasion. Moses Gun Conference, Department of Surgery, University of Michigan, USA, 2008
10. Hasan MR, Chatttopadhyay TK, Gupta SD, Chauhan SS and Ralhan R. Clinical significance of Slug in esophageal squamous cell carcinoma. ACBICON, Dec. 17-20, 2007 New Delhi.
11. Kausar T, Lin L, Thomas D, Ahsan A, Hasan MR, Ralhan R and Beer DG. GPR56 is frequently overexpressed in esophageal adenocarcinoma and may affect tumor invasion. Cancer Center Symposium, University of Michigan, USA, 2007.

• Workshop Attended

1. Participated in Workshop on the innovative technique the Real Time PCR, May 2, 2008, New Delhi
2. Participated in 7th INDO-US Flow cytometry workshop on “Proliferation, apoptosis and signal transduction”. Feb 10-14, 2007, New Delhi, India

• Awards & Fellowship:

1. Received Postdoctoral Research Associate Grant from Indian Council for Medical Research, Government ofIndia (2014-2017)
2. National Eligibility Test (NET-JRF) Qualified:Department of Biotechnology, Ministry of Science and Technology, Government of India
3. Received Scholar-in-Training Award in American Association for Cancer Research (AACR)

International Conference on "Advances in Cancer Research: From the Laboratory to the Clinic" held on March 7-10, 2010 at Jordan.

4. Senior Research fellowship (SRF) awarded by Department of Biotechnology (DBT), Ministry of Science and Technology, Government of India – 2008-2011.
5. Received Post Graduation Fellowship (2003-2005)

Department of Biotechnology (DBT) Govt. of India, to study M.Sc. Biotechnology course at Madurai Kamaraj University

6. Received AIIMS Fellowship to carry out Summer Training Program- 2001

 

• Membership:

1. Associate Member American association for cancer research (AACR)
2.  Indian Association of Cancer Research (IACR) 
3. AIIMS, New Delhi, Society of Young Scientist Life member

• Research Skills:

Extensively work on Molecular Biology, Genomics, Proteomics, Molecular Oncology and Clinical Tumor Biology

• Teaching/ Research / Technical Skills:

• Biochemistry: Metabolism of Carbohydrates, Proteins, Lipids, DNA. Gas Chromatograph-Mass Spectrometry (GCMS), High Performance Liquid Chromatography (HPLC), Enzymology, Enzyme kinetics, Protein purification, 2D-Gel-Electrophoresis, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, immunoprecipitation, Co-immunoprecepitation, enzyme linked immunosorbent assay (ELISA), Epigenetics. Clinical Biochemistry for diagnosis of Disease, PCR and Real Time PCR. 

• Immunology:  Basic Immunology, Immunopathogenic Mechanisms/Immunogenetics of Autoimmunity, Tolerance and Autoimmunity, Hematopoiesis and Immune cell development, Stem Cells and Early Lineage Restrictions, Myeloid and Erythroid Cell Development, Lymphoid Organogenesis, B Cell Development, T Cell Development, Signal Pathways in Immune Cell Development, Regulation and Activation, MHC: Evolution and Polymorphisms, Molecular Aspects of Repertoire Formation (Recombination, Isotype Switching, Somatic Mutation), Transcriptional Regulation of the Immune System, Structural Biology of Immune Regulation

 

• Genetics: Basic Genetics, Human Genetics, Application of new genome sequencing technologies, Genome Enabled Biology and Medicine
• Molecular biology : DNA / RNA / protein isolation from animal cells and tissues, Polymerase Chain Reaction (PCR), Reverse Transcription PCR (RT-PCR), Real Time PCR, Polyacyrlamide gel electrophoresis, silver staining of denaturing SDS-PAGE, gene cloning in cloning and expression vectors, expression of recombinant proteins, gene polymorphism, In Situ Hybridization, siRNA transfection, western blotting, cDNA Microarray
• Molecular Oncology: Cancer cell lines, and Human GI cancer samples: siRNA transfection, Wnt signaling and EMT  pathways analysis

Cell Biology techniques: Animal Cell Culture, Fluorescence Microscope, Confocal Microscopy, Flow cytometry (FACS), human samples. , TUNEL assay, annexin-V Assay,

• Computational skills: Microsoft Office, SPSS and STATA software for statistical analysis.

• Leadership /Administrative Responsibility

Currently Head of Scientific Research Unit; Assisted 5 Ph.D., 6 M.Sc., and 4 summer trainees’ students

 

• References:

1. Dr. Anoop Saraya

Professor & Head, Department of Gastroenterology,

All India Institute of Medical Sciences, New Delhi-110029, INDIA,

Phone- +91-11-26593359 FAX:+ 91-11-26588641, 26588663.

Email: ansaraya@yahoo.com

2.     Dr. Kapil Dev

 Associate Professor,

 Department of Biotechnology, Jamia Millia Islamia, New Delhi

 Phone No- 9968408783, 9958887541 

Email. kdev@jmi.ac.in

3. Dr. Shyam S. Chauhan

Professor  & Head, Department of Biochemistry,

All India Institute of Medical Sciences, New Delhi-110029,

 INDIA, Phone-+91- 9810916291

Email:s_s_chauhan@hotmail.com