Cardiovascular disease is a significant cause of global mortality, creating a substantial burden on public health and economy. Research focusing on beneficial food and its active ingredients is essential to mark the health needs. Dates are abundant in polyphenols, particularly flavonoids, micronutrients and dietary fibers, that can influence cardiovascular health and potentially alleviate vascular illness. Based on this, we aimed to systematically review the cardiovascular effects of P. dactylifera. In this study, a systematic-research was performed according to the PRISMA guidelines to collect all relevant studies on “cardio-protective effect of P. dactylifera” using various databases up-to 2024. A total of 109 studies were obtained and evaluated in accordance with pre-selected criteria for inclusion/exclusion and finally 21 studies were included in this review. Evidence from in vitro, in vivo, clinical studies, histological and genetic data indicated that consuming date fruit entirely or its extracts could regulate specific indicators of cardiovascular health, especially level of lipids (triglycerides and cholesterol), markers of inflammation and oxidative stress. Emerging evidence suggest that integrating date fruit and extracts into one's diet could be a beneficial factor of cardiovasculary healthy life.
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